Profil Kadar Trombosit Berdasarkan Tingkat Keparahan Demam Berdarah Dengue Pada Pasien Rawat Inap di RSUD Meuraxa Banda Aceh
DOI:
https://doi.org/10.31004/koloni.v5i3.1415Keywords:
Dengue Hemorrhagic Fever, Platelet Count; Severity.Abstract
Dengue Hemorrhagic Fever (DHF) is a viral infection transmitted by the Aedes aegypti mosquito, characterized by high fever, myalgia, arthralgia, and thrombocytopenia, which may progress to severe bleeding and shock. Hematological abnormalities, particularly thrombocytopenia (platelet count <150,000/μL), serve as critical indicators of clinical severity in dengue infection. This study aimed to determine the profile of platelet counts based on the severity of DHF among hospitalized patients. A quantitative descriptive study with a retrospective approach was conducted at Meuraxa Regional General Hospital in Banda Aceh from April to May 2026. The study population comprised all hospitalized DHF patients in 2025, with a sample of 72 patients selected based on specific inclusion criteria via medical record observations. Data were analyzed using frequency and percentage distributions. The results demonstrated that all Grade I patients presented with mild thrombocytopenia (29 patients, 100%), Grade II patients predominantly exhibited moderate thrombocytopenia (19 patients, 55.9%), Grade III patients mostly had severe thrombocytopenia (5 patients, 71.4%), and all Grade IV patients presented with severe thrombocytopenia (2 patients, 100%). In conclusion, platelet count profiles vary markedly across different clinical severity stages of DHF. Early monitoring of platelet counts is highly recommended to anticipate disease progression and prevent severe complicationsReferences
Ghoshal, K., & Bhattacharyya, M. (2014). Overview of platelet physiology: Its hemostatic and nonhemostatic role in disease pathogenesis. The Scientific World Journal, 2014. https://doi.org/10.1155/2014/781857
Guo, L., Gu, Y., Zhang, Y., Zhang, H., Weng, W., & Wu, S. (2025). Platelet dynamics and thrombocytopenia in dengue fever : A prospective cohort study from Shenzhen , China. New Microbes and New Infections, 67(July), 101624. https://doi.org/10.1016/j.nmni.2025.101624
Gupta, B. P., Uranw, S., Gupta, V. P., Deuba, E., Sah, A. K., Chaudhary, S., & Wagle, C. (2025). Leukopenia and thrombocytopenia in dengue patients: a cross-sectional study from a tertiary hospitals in Koshi Province, Nepal. BMC Infectious Diseases, 25(1). https://doi.org/10.1186/s12879-025-11126-8
Halim, R., & Rifal, M. (2024). Trombositopenia pada Demam Berdarah Dengue. UMI Medical Journal, 9(1), 1–9. https://doi.org/10.33096/umj.v9i1.288
Kafrawi, V. U., Dewi, N. P., & Adelin, P. (2019). Gambaran Jumlah Trombosit dan Kadar Hematokrit Pasien Demam Berdarah Dengue di Rumah Sakit Islam Siti Rahmah Padang. Health & Medical Journal, 1(1), 38–44. https://doi.org/10.33854/heme.v1i1.217
Kementrian, K. R. I. 2025. (2024). Profil Kesehatan Indonesia 2024.
Khan, M. B., Yang, Z. S., Lin, C. Y., Hsu, M. C., Urbina, A. N., Assavalapsakul, W., Wang, W. H., Chen, Y. H., & Wang, S. F. (2023). Dengue overview: An updated systemic review. In Journal of Infection and Public Health (Vol. 16, Issue 10, pp. 1625–1642). Elsevier Ltd. https://doi.org/10.1016/j.jiph.2023.08.001
Khoisiah, H., Sani, N., Sudiadnyani, N., & Hermawan, D. (2025). Hubungan usia dan jenis kelamin dengan kejadian demam berdarah dengue. JOURNAL OF Qualitative Health Research & Case Studies Reports, 5(5), 650–656. https://doi.org/10.56922/quilt.v5i5.1355
Maulin, K., & Irma, F. A. (2023). Hubungan Jumlah Trombosit Dan Hematokrit Dengan Derajat Keparahan Demam Berdarah Dengue Di Rsud Dr. Pirngadi Kota Medan Tahun 2019-2021. Jurnal Implementasi Husada, 4(4), 288–298.
Parveen, S., Riaz, Z., Saeed, S., Ishaque, U., Sultana, M., Faiz, Z., Shafqat, Z., Shabbir, S., Ashraf, S., & Marium, A. (2023). Dengue hemorrhagic fever: a growing global menace. Journal of Water and Health, 21(11), 1632–1650. https://doi.org/10.2166/wh.2023.114
Raihan, Fitriani, E., & Herawati. (2020). Analisis Faktor Risiko Terjadinya Syok pada Anak dengan Demam Berdarah Dengue di RSUD dr . Zainoel Abidin. Journal of Medical Science, 2(1), 74–80.
Rizqa, N. El, Syam, E., & Astiwara, E. M. (2025). Hubungan Kadar Hematokrit dan Trombosit dengan Derajat Penyakit Demam Berdarah Dengue pada Pasien di Rumah Sakit X Jakarta Pusat Periode 2023 dan Tinjauannya Menurut Pandangan Islam The Relationship between Hematocrit and Platelet Levels with the Grade of. Junior Medical Journal, 3(5), 723–732.
Sagar, V., Kumar, S., & Mishra, A. (2024). Clinical-Hematological Profile of Patient with Acute. European Journal of Cardiovascular Medicine, 14(5), 860–864.
Salsabila, A. F., Husada, D., & Puspitasari, D. (2024). Hematology Profiles and Disease Severity of Pediatric Dengue Virus Infection at a Tertiary Hospital in Surabaya , Indonesia. Biomorphology Journal, 34(1), 1–9. https://doi.org/10.20473/mbiom.v34i1.2024.1-9
Tirtadevi, S. N., Riyanti, R., & Wisudanti, D. D. (2021). Korelasi Jumlah Trombosit dan Kadar Hematokrit terhadap Tingkat Keparahan Pasien Demam Berdarah Dengue di RSD dr. Soebandi Jember. Journal of Agromedicine and Medical Sciences, 7(3), 156–161. https://www.academia.edu/download/76326833/9934.pdf
Tjahjono, G., Widiyansi, P., & Narsonudin. (2016). Clinical Manifestation Approach Of Dengue Viral Indection. Indonesia Journal of Tropical and Infecious Disease, 6(2), 39–45.
Witte, P., Venturini, S., Meyer, H., Zeller, A., & Christ, M. (2024). Dengue Fever—Diagnosis, Risk Stratification, and Treatment. Deutsches Arzteblatt International, 121(23), 773–778. https://doi.org/10.3238/arztebl.m2024.0175
World Health Organization (WHO). (2024). Dengue and Severe Dengue: Key Facts and Global Surveillance Update. World Health Organization, January, 1–7. https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue
World Health Organization Indonesia. (2025). Indonesia and WHO Ramp Up Dengue Fight with Smarter Surveillance. April. https://www.who.int/indonesia/news/detail/16-05-2025-indonesia-and-who-ramp-up-dengue-fight-with-smarter-surveillance
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Edy Cahyady, Cut Kesya Mayla, Aditya Candra
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
