Pengaruh Pemberian Rebusan Daun Kersen (Muntingia Calabura L.) Terhadap Gula Darah pada Penderita Diabetes Melitus: A Systematic Literature Review

Yanti Yolanda; Risma Melinda; Winda Indriyani; Cicirosnita J. Idu; Alfika Safitri

doi:10.31004/koloni.v5i3.1365

Authors

Yanti Yolanda Universitas Yatsi Madani
Risma Melinda Universitas Yatsi Madani
Winda Indriyani Universitas Yatsi Madani
Cicirosnita J. Idu Universitas Yatsi Madani
Alfika Safitri Universitas Yatsi Madani

DOI:

https://doi.org/10.31004/koloni.v5i3.1365

Keywords:

Muntingia calabura L., boiled cherry leaf, blood glucose level, diabetes mellitus.

Abstract

Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels due to impaired insulin secretion, insulin action, or both. Blood glucose control can be achieved through pharmacological and non-pharmacological therapies. One of the non-pharmacological therapies that has been widely investigated is boiled cherry leaf (Muntingia calabura L.), which contains bioactive compounds such as flavonoids, saponins, tannins, and polyphenols that may help reduce blood glucose levels. Study Objective: To analyze the findings of studies on the effect of boiled cherry leaf (Muntingia calabura L.) decoction on blood glucose levels in patients with diabetes mellitus through a Systematic Literature Review. Research Method: This study employed a Systematic Literature Review approach. Articles were searched through the PubMed, Google Scholar, ResearchGate, and ScienceDirect databases with a publication period from 2016 to 2026. Article selection was conducted using the PICOS framework based on predetermined inclusion and exclusion criteria. The quality of the articles was assessed using the JBI Critical Appraisal Checklist for Quasi-Experimental Studies. Research Results: A total of 2,051 articles were identified through the literature search process, and 10 articles met the eligibility criteria for analysis. The synthesis showed that the administration of boiled cherry leaf (Muntingia calabura L.) reduced blood glucose levels from 166.90–546.11 mg/dL to 141.70–322.97 mg/dL, accompanied by changes in blood glucose categories from diabetes to prediabetes, high to normal, and uncontrolled (86.7%) to controlled (80.0%). Conclusion: The findings of this Systematic Literature Review indicate that boiled cherry leaf (Muntingia calabura L.) has an effect on changes in blood glucose levels among patients with diabetes mellitus and may be considered as a complementary therapy in diabetes mellitus management.

References

American Diabetes Association. (2026). Diagnosis And Classification Of Diabetes : Standards Of Care In Diabetes — 2026. 49(January), 27–49.

Balan, T., Rosman, F. H., Rajendhiran, L., Ghazali, N. A. H., Murugesu, S., Fatinathan, S., Zakaria, Z. A., Gnanaraj, C., & Perumal, V. (2023). Antidiabetic Property Of Muntingia Calabura: A Review. Asian Of Medicine & Health Sciences, 6(2), 68–85. Https://Ejournal.Unikl.Edu.My/Index.Php/Ajmhs/Article/View/180?Utm_Source=Chatgpt.Com

Bina, J., Husada, C., Juli, N., Kesehatan, J., Science, D., Rakhmawati, A., & Asnaniar, S. (2025). Profil Nilai Tekanan Darah Penderita Diabetes Melitus Dengan Kadar Glukosa Darah Yang Tidak Terkontrol. 21(2), 106–115.

Fauziyah, E., & Zaifah, S. (2023). Self Efficacy Pencegahan Komplikasi Hipertensi Dengan Tingkat Pendidikan Menengah Dan Tinggi. Jurnal Sains Dan Teknologi Kesehatan, 5(1), 25–31.

Febriyona, N. R. K. R. (2025). Pengaruh Rebusan Daun Kersen Terhadap Penurunankadar Glukosa Darah Pada Penderita Diabetesmelitus Tipe 2 Di Kelurahan Hutuo Kabupaten Gorontalo. Journal Of Tscners, 10(1).

International Diabetes Federation. (2025). Idf Diabetes Atlas. Https://Diabetesatlas.Org/Resources/Idf-Diabetes-Atlas-2025/

Marlin Sutrisna. (2023). Pengaruh Air Rebusan Daun Muntingia Calabura L Terhadap Kadar Gula Darah Pasien Diabetes Mellitus Tipe Ii : Sistematic Review 3 Rd E-Proceeding Senriabdi 2023. 3, 113–124.

Muhammad Nurman, R. M. (2018). Pengaruh Pemberian Daun Seri Terhadap Penurunan Kadar Gula Darah Pada Penderita Diabetes Melitus Di Kelurahan Bangkinang Kota Wilayah Kerja Puskesmas Bangkinang Kota. 2(23), 95–101.

Porina R, Wira Ekdeni A, F. S. (2020). The Effect Of Giving Kersen Leaves ( Muntingia Calabura L .) On Blood Sugar Levels Of. Jurnal Kesehatan Global, 3(3), 123–129.

Ranteallo, R. R., Manginte, A. B., & Mapandin, A. (2022). Diabetes Melitus Pada Masyarakat Di Sa ’ Dan Malimbong * Correspondent Author : Yahya Handayani Pendahuluan Seiring Dengan Berkembangnya Zaman , Kebutuhan Manusia Yang Tinggi Saat Ini Menyebabkan Mereka Lupa Mengontrol Terhadap Asupan Makanan Yang Masuk K. Jurnal Ilmiah Kesehatan Promotif, 7.

Rista Riviani, Erna Mutiara, Heru Santosa, & Arifa Masyitah. (2025). Analisis Spasial Kasus Diabetes Melitus Dan Faktor Risiko Di Provinsi Sumatera Utara Tahun 2023. Jurnal Pengabdian Masyarakat Dan Riset Pendidikan, 4(1), 972–979. Https://Doi.Org/10.31004/Jerkin.V4i1.1683

Roihatul Zahroh, M. (2016). Pemberian Rebusan Daun Kersen Menurunkan Kadar Glukosa Darah Pasien Diabetes Mellitus Tipe 2 (Influence Of The Cherry Decoction Leaves Decrease In Blood Glucose Levels). Journal Of Ners Community, 07(November), 102–108.

Simatupang, R. (2023). The Effect Of Provision Of Cherry Leaves Booked Water On The Reduction Of Blood Sugar Levels In Type 2 Diabetes Mellitus Patients. 10(6), 3–8.

United Nations. (2024). Goal 3: Ensure Healthy Lives And Promote Well-Being For All At All Ages. United Nations Sustainable Development Goals. Https://Sdgs.Un.Org/Goals/Goal3

World Health Organization. (2024). Diabetes. World Health Organization. Https://Www.Who.Int/News-Room/Fact-Sheets/Detail/Diabetes

Zakiah Rahman, R. (2020). Pengaruh Air Rebusan Daun Ceri Terhadap Kadar Gula Darah Pada Pasien Diabetes Mellitus Tipe 2 Dipuskesmas Tanjungpinang Kota. Jurnal Keperawatan, 10(2), 75–82.

Zakiah Zahra, Solihati, Z. M. S. (2026). The Influence Of Boiled Cherry Leaf Water (Muntingia Calabura) On Blood Glucose Level Changes In Diabetes Mellitus Patients. Jurnal Riset Media Keperawatan, 9(1), 1–7.